Protein Structure Prediction
We break down the protein structure prediction field: methods beyond AlphaFold, complex prediction, and the gap to experimental validation — and what it means for real drug development.
Protein structure prediction has grown from benchmark contests into a drug-discovery tool. After AlphaFold, ESMFold and RoseTTAFold compete on speed, open weights and new tasks — mainly complexes, the interacting pairs that decide viral functions and binding sites. CASP remains the impartial judge. The clinic road hinges on hard problems: dynamic structures, lab-failed predictions. We sort methods, benchmarks, genuine progress.
